Evaluation of analgesic effects of ketamine versus dexmedetomidine as an adjuvant to 0.2% ropivacaine infusion in adductor canal block for post-operative analgesia following unilateral total knee replacement surgery.
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Number of patients requiring additional opioids following ketamine versus dexmedetomidine as an adjuvant to ropivacaine infusion in adductor canal block
研究概览
简要总结
TKR is associated with associated with severe pain during post operative period . Therefor post operative pain management is of utmost importance for patient outcome and satisfaction .
The current practice is to manage post operative pain with adductor canal block using local anaesthetic agents which provide good analgesia while preserving motor function . Various adjuvants have been used to prolong the duration of action of nerve blocks . In this study we plan to compare adjuvant effects of ketamine ( 1mg/kg ) and dexmedetomidine ( 1mcg/kg ) . Through a comparative analysis , this study aims to determine the optimal adjuvant for enhancing post operative pain management while minimizing adverse effects .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 50.00 Year(s) 至 85.00 Year(s)（—）
- 性别
- All
入选标准
- •American society of anaesthesiologist physical status I-III.
排除标准
- •Allergy to local anaesthetics 2) Patient with history of previous knee surgeries 3) Patients with contra indications to spinal anaesthesia 4) Patients with history of chronic analgesic use.
结局指标
主要结局
Number of patients requiring additional opioids following ketamine versus dexmedetomidine as an adjuvant to ropivacaine infusion in adductor canal block
时间窗: 24 hours post operatively
次要结局
- 1 )Hemodynamic changes(2 ) To assess motor blockade)
研究者
Dr Gokuldas Sekhara Menon
Amrita institute of medical science and research centre