NCT01326208Unknown2 期
Influence of Different Strategies to Optimize Positive End-expiratory Pressure on Pulmonary Gas Exchange, Perfusion/Ventilation Matching and Homogeneity of Ventilation in Patients With Acute Lung Injury
University Hospital, Bonn2 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2011年3月1日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- homogeneity of regional ventilation delay
研究概览
简要总结
The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange, lung mechanics, ventilation/perfusion matching and homogeneity of regional ventilation when compared to other PEEP setting strategies such as the open lung concept or the ARDSnet protocol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute lung injury, need for optimization of ventilatory settings
排除标准
- •preexisting chronical lung disease, pneumothorax, pace maker, hemodynamical instability, increased intracranial pressure
结局指标
主要结局
homogeneity of regional ventilation delay
时间窗: up to eight hours
influence of different PEEP titration strategies on homogeneity of regional ventilation delay measured by electrical impedance tomography
次要结局
- pulmonary gas exchange, lung mechanics and ventilation/perfusion matching(up to eight hours)
研究者
研究点 (2)
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