Evaluation of Non Invasive Fetal Cardiac Functions and Fetal Arterial&Venous Doppler Study in Intrauterine Growth Restriction as Predictive Parameters of Perinatal Outcome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 534
- 试验地点
- 1
- 主要终点
- Cerebroplacental ratio
研究概览
简要总结
Intrauterine growth restriction (IUGR) is one of the major contributors to perinatal mortality and morbidity and is characterized by complex hemodynamic changes involving placental and fetal arterial, cardiac and venous circulations .However, the temporal sequence of these modifications in relation to other hemodynamic changes of the fetal arterial and venous circulations is unknown.
The aim of this study was to evaluate cardiac function and other hemodynamic changes in a group of fetuses with IUGR and clinical impact on perinatal outcome .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Singleton fetus with normal fetal anatomy documented a detailed sonogram.
- •Fetal abdominal circumference <5th percentile for gestational age.
- •Evidence of placental insufficiency documented by an elevated umbilical artery pulsatility index (UA-PI) by reference ranges.
排除标准
- •evidence of fetal infection
- •chorioamnionitis
- •fetal anomalies
- •abnormal fetal karyotype
- •patient withdrawal from the study and/or unavailability for follow-up.
结局指标
主要结局
Cerebroplacental ratio
时间窗: 5 minutes
cerebroplacental ratio = Rtio middle cerebral artery pulsatility index / umbilical artery pulsatility index
Preload Index in inferior vena cava
时间窗: 5 minutes
Preload Index in inferior vena cava = ratio of peak systolic velocity in atrial contraction /peak systolic velocity ventricular systole
Myocardial performance index
时间窗: 5 minutes
Ratio between isovolumetric time to ejection time
Aortic isthmus flow index
时间窗: 5 minutes
Aortic isthmus flow index = Ratio of (systolic velocity time integral+diastolic velocity time integral) / systolic velocity time integral
次要结局
未报告次要终点
研究者
Sief el eslam Ahmed Ali
Principal investigator
Assiut University