Genomics of Small Cell Lung Carcinoma
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Lung Cancer
- 发起方
- Alliance for Clinical Trials in Oncology
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Identification of genetic alterations in human SCLC (driver or passenger mutations)
- 状态
- 已完成
- 最后更新
- 4年前
概览
简要总结
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in tumor tissue and blood samples from patients with small cell lung cancer registered on CALGB-140202.
详细描述
OBJECTIVES: Primary * To identify the major genetic alterations in human small cell lung cancer (SCLC) using next-generation sequencing and focusing on mutations in coding sequence. Secondary * To follow up with in-depth assessment of candidate oncogenes and tumor suppressor genes using gene expression analysis, cell culture systems, and murine models of SCLC. OUTLINE: DNA isolated from archived tumor tissue and blood samples are analyzed for genetic mutations and gene expression profiling using Illumina exome sequencing. Results are compared with transcriptome of tumors (or cell lines) with and without the specific mutation. Cell culture studies overexpressing or inhibiting the genes of interest are also performed in a mouse model to identified potential drivers of small cell lung cancer.
研究者
入排标准
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Identification of genetic alterations in human SCLC (driver or passenger mutations)
时间窗: Baseline
次要结局
- Gene expression between samples with or without mutations(Baseline)