Molecular Characterization of Lung Cancer: A Collaboration With the Cancer Genome Atlas Project (TGCA)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lung Cancer
- Sponsor
- Alliance for Clinical Trials in Oncology
- Enrollment
- 248
- Locations
- 11
- Primary Endpoint
- Identification and characterization of SNVs in primary adenocarcinoma of the lung or squamous cell carcinoma of the lung
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies tissue samples from patients with non-small cell lung cancer.
Detailed Description
OBJECTIVES: * To identify and characterize single nucleotide variations (SNVs) in non-small cell lung cancer (NSCLC) specimens. * To identify and characterize structural variations in the genomes of NSCLC specimens. * To identify and characterize other genomic alterations including, but not limited to, expression profiling and methylation. OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide variations, structural variations in the genomes, and other genomic alterations including, but not limited to, gene expression profiling and methylation. Clinical data related to disease, treatment, and recurrence from each patient sample is also collected.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Identification and characterization of SNVs in primary adenocarcinoma of the lung or squamous cell carcinoma of the lung
Time Frame: up to 5 years
Identification and characterization of structural variations in the genomes of NSCLC
Time Frame: up to 5 years
Identification and characterization of other genomic alterations including, but not limited to, gene expression profiling and methylation
Time Frame: up to 5 years