SPIO- enhanced High Field MRI for restaging lymph node status in rectal cancer: an explorative study - USPIO- enhanced High Field MRI for restaging rectal cancer

Radboud Universitair Medisch Centrum0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年2月28日

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•General criteria:
•- Age > 18 years;Specific ;- Patients with recently histologically proven rectal cancer, who are:;o Planned to undergo neoadjuvant radiotherapy 50.4 Gy with concomitant chemotherapy consisting of capecitabin 825-1000 mg/m2 and/or oxaliplatin 85 mg/m² .;and;o Planned to undergo a total mesorectal excision.

•General exclusion criteria:;- Abdominal circumference > 120cm
•- Pregnancy;- Karnofsky score <= 70;- Contraindications for 3T MRI:
•o Inability to provide informed consent
•o Metal implants that are not compatible with 3 Tesla MRI;- Contraindications to USPIO based contrast agents:
•o prior allergic reaction to ferumoxtran-10 or any other iron preparation
•o prior allergic reaction contributed to dextran or other polysaccharide, in any preparation
•o prior allergic reaction to contrast media of any type
•o hereditary hemochromatosis, thalassemia, sickle cell anemia;;- Contraindications to bisacodyl or butylscopolamine:
•o cardiac arrhythmia,
•o myasthenia gravis,
•o urinary retention,
•o gastrointestinal stenoses,
•o kidney failure
•o glaucoma, ;- Inflammatory diseases of the abdomen (such as Crohn*s disease);- Previous oncological related abdominal and/or pelvic surgery or radiotherapy

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