Relationships Between Sleep Spindle and Cognitive Process in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- Sleep spindle during N2 sleep stage
研究概览
简要总结
Meta-analyses demonstrate that sleep spindles, characterizing NREM sleep, may be a physiological index of high-level cognitive processes. The aim of the study is to determine if sleep spindles can predict interindividual variation in attention and cognitive performance. Relationship between attention and cognitive performance and sleep spindles characteristics (density, frequency and amplitude) recording during 1 night in 80 healthy subject (aged between 18-75y), will be calculated.
详细描述
It is currently well demonstrated that sleep promotes brain plasticity and therefore is directly involved in cognitive processes such as memory, language, reasoning, learning, intelligence, problem solving.... Sleep deprivation affects most cognitive processes. More specifically, it is the sleep microstructure and in particular the sleep spindles that are specifically linked to memory, learning and cognitive abilities. Sleep spindles are grapho-elements that characterize NREM sleep. They exhibit high inter-individual stability and variability, depend on the genetic heritage and correlate with anatomical properties of the brain. Sleep spindles can therefore be considered as an electrophysiological "finger-print" as one of the most heritable traits of humans. Studies support the notion that sleep spindles are electrophysiological markers of high-level cognitive abilities. It remains to be seen whether the sleep spindles can predict interindividual variations in attention and executive functions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female subjects, aged 18 to 75,
- •BMI between 18 and 27,
- •Having no subjective daytime sleepiness (Epworth scale score ≤ 11),
- •Subjects affiliated to a social security scheme,
- •Subjects capable of understanding the study,
- •Subjects available to come to the 2 visits required by the study,
- •Having given written informed consent to participate in the study,
- •Free, informed and written consent, dated and signed by the patient and the investigator before any examination required by the research,
- •For simulated driving sub-study: Having a driving license (subsample).
排除标准
- •Severe pathologies involving the short-term vital prognosis,
- •Uncontrolled endocrine pathologies (dysthyroidism, diabetes),
- •All progressive cardiovascular conditions,
- •All progressive neurological conditions treated or not (brain tumor, epilepsy, migraine, stroke, sclerosis, myoclonus, chorea, neuropathy, muscular dystrophies, myotonic dystrophy ...),
- •Current Psychiatric disorder: mood disorder (depression, bipolar disorder), anxiety disorder, psychosis
- •Substance-related dependence,
- •Shift workers or night workers who have been on call or on call in the last 72 hours,
- •Psychotropic patients,
- •Long-term treatment with benzodiazepines and z-drugs,
- •Patients on cardiotropic,
- •Deprived of liberty by a judicial or administrative decision,
- •Pregnant or lactating woman,
- •Subject under curatorship or tutorship.
- •For simulated driving sub-study: Having simulator-sickness during the first practice session evaluated by Simulator Sickness Questionnaire (SSQ)
结局指标
主要结局
Sleep spindle during N2 sleep stage
时间窗: during experimental visit (between day 1 and day 14 after inclusion)
Characteristics of the sleep spindles generated during the N2 sleep stages. The sleep spindles density will be calculated automatically on the EEG Cz and Fz channels. The amplitude and frequency will be calculated automatically on the EEG Cz and Fz channels. The sleep spindles will also be divided, according to their frequency: into fast zones (13-15 Hz) and slow zones (11-13 Hz).
Sleep spindle during N3 sleep stage
时间窗: during experimental visit (between day 1 and day 14 after inclusion)
Characteristics of the sleep spindles generated during the N3 sleep stage. The sleep spindles density will be calculated automatically on the EEG Cz and Fz channels. The amplitude and frequency will be calculated automatically on the EEG Cz and Fz channels. The sleep spindles will also be divided, according to their frequency: into fast zones (13-15 Hz) and slow zones (11-13 Hz).
次要结局
未报告次要终点