Working Memory Training and Neural Plasticity in Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Changes in brain activation within the WM network
研究概览
简要总结
This study will evaluate the efficacy of working memory training in older adults with amnestic mild cognitive impairment (MCI).
详细描述
Working memory (WM) is the ability to hold information actively in mind and is fundamental for higher-order cognition. This pilot study aims to (1) evaluate the efficacy of WM training in older adults with MCI and (2) understand if and how it works. The study will use behavioral and brain imaging assessments to see whether WM training changes how participants learn and remember information. Functional magnetic resonance imaging (fMRI) and functional near infrared spectroscopy (fNIRS) methods will be used. The study will also use cognitive tests and questionnaires to determine whether participants' cognitive abilities change with training. The study will enroll participants with a diagnosis of MCI as well as cognitively intact older adults (healthy controls, HC).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •MCI Diagnosis
- •Right-handedness
- •MRI-eligibility for MRI participants
排除标准
- •History of other contributing neurological or medical conditions known to affect cognitive functioning
- •Significant mental illness
- •Sensory impairments that limit ability to participate
- •History of alcohol or drug abuse/dependence
结局指标
主要结局
Changes in brain activation within the WM network
时间窗: 2 weeks
Univariate analyses via fMRI and fNIRS, respectively, using units of brain activation (i.e., contrast estimates)
Gains in WM training task performance
时间窗: 2 weeks
Analyses of WM performance for each training session indexed as the mean set-size achieved during each training session for each participant
次要结局
- Changes in criterion (fMRI) WM task performance(2 weeks)
- Changes in functional connectivity within and between canonical brain networks(2 weeks)
研究者
Alexandru Iordan
Principal Investigator
University of Michigan