NCT04648059Unknown不适用
Unmethylated CpG-rich DNA Fragments in TLR-mediated Renal Fibrogenesis of Lupus Nephritis
University of Göttingen1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2020年12月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Methylated CpG-rich DNA fragments
研究概览
简要总结
This is a translational study for the identification of epigenetic changes detectable in sera of patients suffering from Systemic Lupus erythematosus. The aim of the study is to analyze whether circulating DNA fragments are 1) different in patients with or without Lupus nephritis and 2) present and detectable in the circulation before the development of Lupus nephritis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of systemic lupus erythematosus according to the current classification criteria
- •a subgroup requires the presence of Lupus nephritis (no restriction to specific LN histologic subtypes)
排除标准
- •patients not able or unwilling to provide written informed consent
结局指标
主要结局
Methylated CpG-rich DNA fragments
时间窗: 12 months
it will be analyzed whether circulating CpG-rich DNA fragments are present in patients' blood
次要结局
未报告次要终点
研究者
Peter Korsten
Principal Investigator
University of Göttingen
研究点 (1)
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