Factors That Determine the Responses to Meal Ingestion: Effect of Previous Diet
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Change in digestive well-being induced by comfort meal
研究概览
简要总结
Meal ingestion induces digestive responses associated to homeostatic and hedonic sensations. The responses to meal ingestion are modulated by conditioning factors. Single-centre, cross-over, random, open label study comparing the effect of a high-fat/low-residue diet versus low-fat/high residue diet on the responses to meal ingestion. In 20 healthy subjects each diet will be administered during 2 weeks in random order; each diet will be preceded by 2 weeks washout, balanced diet. The aim of the study is to compare the effects of each diet on the responses to comfort and flatulogenic meals, intestinal gas production and digestive sensations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non-obese
排除标准
- •history of gastrointestinal symptoms
- •prior obesity
- •use of medications
- •history of anosmia and ageusia
- •current dieting
- •alcohol abuse
- •psychological disorders
- •eating disorders
研究组 & 干预措施
High-fat diet
干预措施: High-fat diet (Other)
High-residue diet
干预措施: High-residue diet (Other)
结局指标
主要结局
Change in digestive well-being induced by comfort meal
时间窗: 1 day
Change in digestive well-being measured by a 10 cm scale graded from -5 (extremely unpleasant sensation) to +5 (extremely pleasant sensation) in response to comfort meal during high-fat versus high-residue diet by repeated measures ANCOVA.
次要结局
- Change in fullness sensation induced by comfort meal(1 day)
- Change in hunger/satiety induced by comfort meal(1 day)
- Change in mood induced by comfort meal(1 day)
- Intestinal gas evacuation in response to a flatulogenic meal.(1 day)
- Intestinal gas production(2 days)
- Sensation of flatulence(2 days)