Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- postoperative pain score
研究概览
简要总结
The purpose of this study is to evaluate the use of an injectable combination of bupivacaine and meloxicam (Zynrelef) vs injectable liposomal bupivacaine (Exparel), two extended local anesthesia strategies currently approved by FDA and on the market for post-surgical pain control. The investigators plan on randomizing study participants to either Exparel or Zynrelef at the closure site of robotic sleeve gastrectomy and assessing their pain control postoperatively both in the hospital and at home. The investigators will measure the outcome of two drugs, Zynrelief, and Exparel on postoperative pain score -using the NRS pin score up to 72 hours after surgery. The total opioid use will be recorded in forms that will be used to measure pain score and total opioid use and will be collected to the Excel sheet. The cost of the drug will be calculated for internal use for Hospital purpose only.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age range: 18-65 years old
- •Scheduled or being scheduled to undergo robotic sleeve gastrectomy by Dr. Goyal.
- •Is able to provide written informed consent.
- •Is able to adhere to the study visit schedule and complete all study assessments.
排除标准
- •Positive urine drug screen prior to surgery
- •History of substance abuse in the past year-by self report
- •Patient with ongoing daily narcotic use at the time of surgery-by self report
- •Inability to understand informed consent or read English/Spanish
- •Pregnant or lactating patients
- •Patients with renal or hepatic failure
- •Bupivacaine use within 96 hours of operation
- •Patient intolerant of opiates, nonsteroidal anti-inflammatory drug s, acetaminophen, or Zynrelef and Exparel. Subjects in all cohorts must not have any contraindications to any of the protocol-specified drugs
- •Patient with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients
研究组 & 干预措施
Patients who receive exparel
those who get exparel injected at the 12mm port incision
干预措施: Exparel (Drug)
Patients who receive zynrelef
Those who get zynrelef injected at the at the 12mm port incision
干预措施: Zynrelef (Drug)
结局指标
主要结局
postoperative pain score
时间窗: 72 hours
this will be measured using a numerical rating scale. The scale is 0-10 with 0 being no pain and 10 being the worst pain of their life
次要结局
- Total postoperative opioid use(72 hours)
- Proportion of total rescue medication use(72 hours)