Investigating Age-dependent Effects of Egg Intake on HDL and Immune Profiles
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Change in serum concentration of large HDL particles between diet periods
研究概览
简要总结
The goal of this intervention study is to determine whether consumption of different fractions of chicken eggs, including egg whites, egg yolks, and whole eggs, confer different changes in markers of HDL function and T cell profiles in younger vs. older men and women. The study will address the following objectives:
- Objective 1: Determine if daily consumption of egg fractions differentially alter HDL profiles across age groups.
- Objective 2: Determine if daily consumption of egg fractions differentially alter immune cell profiles across age groups.
Participants will be asked to consume egg whites, egg yolks, and whole eggs on a daily basis for 4-weeks each, and avoid eating eggs for a total of 8 weeks at different points in the study. Participants will additionally be provided guidance on following a generally healthy diet, and will be asked to complete surveys about dietary intake and physical activity, as well as provide blood samples throughout the course of the study.
Researchers will compare whether daily consumption of egg whites, egg yolks, and whole eggs differentially alter markers of HDL function and T cell profiles in younger vs. older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-30 years old, or 50-75 years old (at time of screening)
- •Body mass index (BMI) < 30 kg/m2
- •Willing to consume whole eggs, egg whites, or egg yolks on a daily basis during study periods, and refrain from eating eggs during other study periods
- •Do not fit any
排除标准
- •Exclusion Criteria:
- •< 18 years old; 31-49 years old; > 75 years old
- •BMI ≥ 30 kg/m2 or body weight < 110 pounds
- •Weight changes > 10% over the last 4 weeks
- •Self-reported history of diabetes, heart disease, stroke, renal or liver disease, cancer, eating disorders, certain severe and/or relapsing/remitting autoimmune, inflammatory, or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation
- •Allergy or intolerance to eggs, egg components, or egg products
- •Implanted medical device (e.g., pacemaker) or other health condition that would prevent measurement of body composition by bioelectrical impedance
- •Highly elevated fasting lipid and glucose levels (triglyceride levels higher than 500 mg/dL, fasting glucose higher than 126 mg/dL), or total cholesterol < 120 mg/dL and HDL-cholesterol < 15 mg/dL
- •Currently taking lipid-lowering medications (e.g. statins, fibrates), anti-inflammatory medications (e.g., NSAIDs, corticosteroids), or medications that primarily affect blood clotting (e.g., warfarin)
研究组 & 干预措施
Egg whites
3 large egg equivalent of liquid egg whites per day for 4 weeks
干预措施: Egg whites (Other)
Egg yolks
3 large egg equivalent of liquid egg yolks per day for 4 weeks
干预措施: Egg yolks (Other)
Whole eggs
3 large whole eggs per day for 4 weeks
干预措施: Whole eggs (Other)
结局指标
主要结局
Change in serum concentration of large HDL particles between diet periods
时间窗: 4 weeks
Measurement of serum large HDL particles (nmol/L) at the egg-free run-in period and the end of each intervention arm.
次要结局
未报告次要终点
研究者
Catherine Andersen
Associate Professor
University of Connecticut