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临床试验/NCT04946487
NCT04946487Unknown不适用

Effect of the Posterior Ligamentous Complex on the Adjacent Segments Degeneration After Lumbar Surgery

Peking University Third Hospital0 个研究点目标入组 80 人开始时间: 2021年7月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
80
主要终点
the Incidences of adjacent segment degeneration

研究概览

简要总结

To investigate whether destroying the adjacent posterior ligamentous complex (PLC) has an effect on adjacent segment degeneration (ASD) after L5/S1 posterior lumbar interbody fusion (PLIF)

详细描述

Purpose: To investigate whether destroying the adjacent posterior ligamentous complex (PLC) has an effect on adjacent segment degeneration (ASD) after L5/S1 posterior lumbar interbody fusion (PLIF).

Methods: This retrospective study was performed in patients who received L5/S1 PLIF with pedicle screw instrumentation for lumbar spinal stenosis with or without isthmic spondylolisthesis. They were divided into the total laminectomy group, which had destruction of the PLC of the adjacent segment, or partial laminectomy group, which did not. Vertebral slip, osteophytes, disk height, and range of motion were examined by plain radiography, and thickness of the ligamentum flavum (LF) and anteroposterior diameters of the lumbar vertebral body and spinal canal were assessed by magnetic resonance imaging (MRI). Disc degeneration and spinal stenosis on MRI scans were categorized. The incidence of ASD and clinical outcome were compared between the groups.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
25 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • typical clinical symptoms such as disabling low back or leg pain with or without neurological symptoms, intermittent claudication, with refractory to ≥6 months of strict conservative treatment; and L5/S1 single-level PLIF with pedicle screw instrumentation.

排除标准

  • previous spine surgery, acute spinal fracture, infection, and tumor.

结局指标

主要结局

the Incidences of adjacent segment degeneration

时间窗: From the end of treatment to more than 8 years

the Incidences of adjacent segment degeneration

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

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