The Role of Histamines on Central Hemodynamics
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Systolic pulmonary artery pressure
研究概览
简要总结
When we exercise, more blood flow goes to our muscles, challenging our blood vessels. Following exercise, blood flow remains elevated and seems to be the reason for many of the positive cardiovascular benefits that occur with exercise. When the actions of histamine, a molecule primarily known for its role in allergies, are blocked, there is an attenuated blood flow response following exercise. However, this effect has never been studied in the blood vessels that supply our lungs. The purpose of this study is to examine the effects of histamines on pulmonary hemodynamics following exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Willing to visit the lab on 3 separate occasions.
排除标准
- •Previously diagnosed heart condition,
- •Previously diagnosed lung condition (including asthma),
- •Previously diagnosed metabolic condition,
- •Currently smokers (cigarettes, electronic cigarettes, cannabis) or who have smoked within the last 3 months,
- •Resting blood pressure >140/90 mmHg,
- •Unable to obtain appropriate quality ultrasound images of the heart.,
- •Individuals without tricuspid regurgitation at rest to allow assessment of the primary outcome,
- •Pregnant or trying to become pregnant,
- •Breastfeeding,
- •Chronically take antihistamines (i.e. daily),
- •History of adverse reactions to antihistamines,
- •Never taken antihistamines previously,
- •Currently taking any medications (including oral contraceptives).
研究组 & 干预措施
Blockade + Exercise Bout
Participants will ingest histamine H1 receptor blockade before performing an exercise bout.
干预措施: Diphenhydramine hydrochloride (Drug)
Blockade + Exercise Bout
Participants will ingest histamine H1 receptor blockade before performing an exercise bout.
干预措施: Exercise Bout (Other)
Placebo + Exercise Bout
Participants will ingest a placebo before an exercise bout.
干预措施: Placebo (Other)
Placebo + Exercise Bout
Participants will ingest a placebo before an exercise bout.
干预措施: Exercise Bout (Other)
结局指标
主要结局
Systolic pulmonary artery pressure
时间窗: Pre-exercise and 10, 20, and 30-minutes post-exercise.
The difference in systolic pulmonary artery pressure (measured as tricuspid regurgitation velocity using echocardiography) between the H1 blockade condition and the placebo condition.
次要结局
- Tricuspid annular plane systolic displacement(Pre-exercise and 0, 10, 20, 30, 45, and 60 minutes post-exercise.)
- Right ventricular stroke volume(Pre-exercise and 0, 10, 20, 30, 45, and 60-minutes post-exercise.)
- Femoral artery blood flow(Pre-exercise and 0, 10, 20, 30, 45, and 60-minutes post-exercise.)
- Mean arterial systemic pressure(Pre-exercise and 0, 10, 20, 30, 45, and 60-minutes post-exercise.)
研究者
Neil Eves
Professor
University of British Columbia