NCT07569289尚未招募2 期
Triggering Oocyte Maturation in POSEIDON Group 3 and 4 Poor Responders Using Double Trigger or HCG Trigger . A Randomized Controlled Study
Bedaya Hospital1 个研究点 分布在 1 个国家目标入组 164 人开始时间: 2026年6月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 164
- 试验地点
- 1
- 主要终点
- Metaphase-II oocytes rate
研究概览
简要总结
The aim of this randomized controlled study is to compare the efficacy of double trigger protocol [ the co-administration of GnRH agonist with HCG ( 38 - 39 and 35 - 36 h prior to ovum pick-up, respectively ] with HCG in triggering ovulation in patients with expected poor response to ovarian stimulation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •POSEIDON group 3 and 4
- •GnRH antagonist IVF cycle
排除标准
- •Hypogonadotrophic hypogonadism
- •Endometriosis
- •History of recurrent abortion
研究组 & 干预措施
Double trigger
Experimental
GnRH agonist is administered 38 - 39 hours prior to ovum pick-up and HCG is administered 35 - 36 hours prior to ovum pick-up, respectively.
干预措施: Double trigger (Drug)
HCG trigger
Active Comparator
HCG is administered 35 - 36 h prior to ovum pick-up
干预措施: HCG trigger (Drug)
结局指标
主要结局
Metaphase-II oocytes rate
时间窗: Ten to fifteen days after starting ovarian stimulation
Number of MII oocyte/ number of cumulus oocyte complex
次要结局
- Clinical pregnancy rate(Five weeks after embryo transfer)
- Ongoing pregnancy Rate(Eighteen weeks after embryo transfer)
研究者
研究点 (1)
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