Brain Perfusion in Pantothenate Kinase-Associated Neurodegeneration (PKAN)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- ASL-derived cerebral blood flow(CBF)
研究概览
简要总结
The purpose of this study is to learn whether blood flow in the brain is normal in people with pantothenate kinase-associated neurodegeneration (PKAN). Specifically, preliminary data suggest a region of the brain called the globus pallidus (GP), a key region affected by PKAN, may have reduced blood flow. Standard MRI and perfusion scanning techniques will be used to learn about cerebral blood flow in the globus pallidus and compare it to blood flow in other brain regions as well as to healthy controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 7 Years 至 75 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosis of PKAN confirmed by MRI and gene testing
- •able to undergo MRI for approximately 1 hour without sedation
排除标准
- •deep brain stimulators or other conditions that warrant avoidance of a strong magnetic field
- •previous reaction to gadolinium (Gd) contrast agent
- •acute or chronic kidney dysfunction
- •pregnant and/or nursing at time of study
结局指标
主要结局
ASL-derived cerebral blood flow(CBF)
时间窗: Single MRI
The unit of analyses will be the subject and the primary comparison will be the globus pallidus CBF between PKAN and healthy controls.
次要结局
未报告次要终点
研究者
Susan J. Hayflick
Professor & Chair, Molecular & Medical Genetics
Oregon Health and Science University