Retinol-binding Protein 4 (RBP4) Metabolizm in Type 2 Diabetes Progression and Associated Cardiovascular Complications
试验速览
- 阶段
- 不适用
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- serum RBP4 level
研究概览
简要总结
Retinol-binding protein 4 (RBP4) may affects obesity development and the development of obesity-related diseases including insulin resistance, type 2 diabetes, steatohepatitis and cardiovascular disease. This study aims to examine the involvement of RBP4 in patients with diagnosed diabetes, diabetic cardiovascular disease, pre-diabetes (pre-DM) and healthy controls during the progression of T2DM, and to evaluate the ability of RBP4 to predict cases of diabetes with an elevated risk of cardiovascular complications . Along with animal experiment.
详细描述
A total of 500 Chinese patients admitted to the First Affliated Hospital of Xi'an Jiaotong University (Xi'an, China) between March 2020 and March 2022 were recruited to investigate the RBP4 profles. Peripheral blood samples are drawn at the initial medical examination, in the morning after a fast of at least 8 h, and immediately stored at -80˚C until the sphingolipid measurements were performed.
Blood pressure, WC, hip circumference (HC), body weight and body height were measured by a trained physician. The participants enrolled in the study provided written informed consent.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Fasting plasma glucose (FPG)≥7.0 mmol/l;
- •2 h plasma glucose (2hPG) ≥11.1 mmol/l;
- •glycated hemoglobin (HbA1c) level ≥6.5%;
- •random plasma glucose ≥11.1 mmol/l plus symptoms of hyperglycemia;
- •T2DM diagnosed previously.
- •Pre-DM was defned as follows:
- •FPG ≥5.6-6.9 mmol/l
- •2hPG 7.8-11.0 mmol/l
- •HbA1c 5.7-6.4%.
排除标准
- •type 1 diabetes
- •liver or kidney disorders.
结局指标
主要结局
serum RBP4 level
时间窗: 2022.3
serum RBP4 level in DM, pre-DM, CVD, DM-CVD and healthy controls.
次要结局
未报告次要终点