Prospective Study on Endothelial Function in Subjects With Type 2 Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 69
- 试验地点
- 1
- 主要终点
- Change in eGFR after 1 year
研究概览
简要总结
Basal nitric oxide (NO) activity plays a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments its alteration has been associated with morphological changes characteristic of diabetic nephropathy. The investigators aimed to assess in a prospective study: 1. basal NO activity of renal vasculature and 2. renal hemodynamics to examine whether impairment of basal NO activity of the renal vasculature is related to development and progression of diabetic nephropathy and other cardiovascular endpoints.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 Diabetes mellitus
排除标准
- •Macroalbuminuria
- •Symptomatic cardiovascular disease
研究组 & 干预措施
A
Subjects with type 2 diabetes mellitus, eGFR > 80, hypertension, no overt proteinuria
干预措施: Telmisartan 80 mg/d (Drug)
B
Subjects with type 2 diabetes mellitus, eGFR > 80, hypertension, no overt proteinuria
干预措施: Ramipril 10 mg/d (Drug)
结局指标
主要结局
Change in eGFR after 1 year
次要结局
未报告次要终点