Endothelial Microparticles as Potential Biomarkers for Endothelial Dysfunction in Hypercholesterolemia and Its Correlation With Pulse Wave Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- EMP level and its correlation with endothelial function by pulse wave analysis
研究概览
简要总结
Endothelial microparticles (EMP) have a promising role as a diagnostic and prognostic tool in the assessment of endothelial function. This study compares the levels of EMP in hypercholesterolaemia patients before and after treatment with statins and correlates it with the current method of assessing endothelial function using pulse wave analysis.
The current available methods to assess endothelial function are tedious and not suitable to be applied clinically. Detecting EMP levels are simpler as it only involves routine blood taking which is better tolerated by patients.
Outcome from this study will contribute to finding a potential diagnostic, prognostic and treatment assessment tool that is suitable to be used clinically. This will have a large impact in the management of cardiovascular-related disease that is prevalent worldwide and increasing in the developed countries.
详细描述
General study objective
To evaluate EMP as a simple diagnostic tool in assessing endothelial function in hypercholesterolaemic patients.
Specific objectives:
- To compare the levels of EMP ( Cluster of differentiation (CD)144, CD62e and CD31+/42-) in hypercholesterolaemics before and after statin.
- To correlate the levels of EMP with the assessment of endothelial function using pulse wave analysis (PWA) in hypercholesterolaemics before and after statin.
Research design
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hypercholesterolaemia: ( LDL >4.1 mmol/l)
- •Age 35 years and above
- •Agreeable to the treatment with statin if indicated
排除标准
- •Pregnancy and breast feeding
- •Serious medical illness eg kidney failure, liver failure, stroke and malignancy.
- •Contraindicated to statin
研究组 & 干预措施
hypercholesterolemia
3-hydroxy-3-methylglutaric acid coenzyme A (HMG Co-A) reductase inhibitor Types of drug, dosage and frequency is according to the treating physician. This is an observational study.
Duration of treatment: 3-5 months
干预措施: HMG-CoA Reductase Inhibitor (Drug)
结局指标
主要结局
EMP level and its correlation with endothelial function by pulse wave analysis
时间窗: 3 months (Fourth visit)
EMP level: absolute count Endothelial function by pulse wave analysis
次要结局
未报告次要终点
研究者
Nik Nor Izah Nik Ibrahim
Principal Investigator
Universiti Sains Malaysia