Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Pregnancy rate
研究概览
简要总结
The purpose of this study is to evaluate the clinical pregnancy rate per embryo transfer in oocytes recipients obtained after ovarian stimulation during the luteal phase of oocytes donors . This study will be performed in egg recipients and donors but this type of treatment is meant to be implemented in fertility preservation patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •premenopausal women, 18-35 years old, FSH levels < 10 mIU/ml; AFC> 10
- •regular cycles
- •BMI < 28
- •signed informed consent
- •Recipients:
- •Infertile women eligible for oocytes donation
- •BMI < 35
- •Signed informed consent form
排除标准
- •Polycystic ovarian syndrome, gonadotropins allergy
- •Recipients:
- •Women eligible for oocytes donation
- •Uncontrolled Endocrine Pathology
研究组 & 干预措施
Lutheal phase ovarian stimulation
Early luteal phase Controlled ovarian hyperstimulation: we will administer in the 13th-15th cycle day simultaneously 0.25 mg/day of ganirelix to induce luteolysis and FSHr (dose according to BMI and AFC )IU/day for controlled ovarian hyperstimulation until achieving criteria for hCG , to induce final oocyte maturation. Mature oocytes will be vitrified. After warming, oocytes will be inseminated by ICSI with the recipients partners semen sample . Recipient endometrium will be primed with estrogen and progesterone , and embryo transfer will be performed on the 3rd day 3 of embryo cleavage.
干预措施: gonadotropins plus GnRH antagonists (Drug)
Lutheal phase ovarian stimulation
Early luteal phase Controlled ovarian hyperstimulation: we will administer in the 13th-15th cycle day simultaneously 0.25 mg/day of ganirelix to induce luteolysis and FSHr (dose according to BMI and AFC )IU/day for controlled ovarian hyperstimulation until achieving criteria for hCG , to induce final oocyte maturation. Mature oocytes will be vitrified. After warming, oocytes will be inseminated by ICSI with the recipients partners semen sample . Recipient endometrium will be primed with estrogen and progesterone , and embryo transfer will be performed on the 3rd day 3 of embryo cleavage.
干预措施: ganirelix (Drug)
结局指标
主要结局
Pregnancy rate
时间窗: six weeks after transfer procedure
次要结局
- Number of Mature oocytes(Day of oocyte retrieval)