Effect of a Kidney Bundle on the Occurence of Postoperative Acute Kidney Injury in Patients at Risk
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Incidence of postoperative AKI
研究概览
简要总结
Postoperative acute kidney injury (AKI) refers to increased mortality and morbidity in patients after non-cardiac surgery. The Kidney Disease Improving Global Outcomes (KDIGO)-guidelines recommend a bundle of procedures to prevent the occurrence of AKI: A protocol for the improvement of the hemodynamic situation and a standardized proceeding in hemodynamic monitoring, consequent avoidance of nephrotoxic substances, regular measurement of creatinine and urine output, as well as normoglycemia. The primary goal is to determine if the consequent application of the KDIGO-bundle leads to a prevention of the occurrence of AKI in patients at risk after non-cardiac surgery.
详细描述
All patients included in the study will be treated with the KDIGO-bundle (hemodynamic stabilization, avoidance of nephrotoxic substances, normoglycemia and measurement of creatinine in serum and urine output). 12 h, 24h as well as on day 2, 3, 5 and 10 after admission on ICU the occurence of AKI (according to KDIGO) will be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
kidney treatment bundle (KDIGO)
Consequent postoperative application of a kidney treatment bundle: Protocol based hemodynamic optimization and monitoring, regular screening of creatinine in serum and of urine output, no use of potential nephrotoxic medication and normoglycemia.
干预措施: kidney treatment bundle (KDIGO) (Procedure)
结局指标
主要结局
Incidence of postoperative AKI
时间窗: until day 5 after surgery
AKI according to KDIGO definition
次要结局
- urine output (total ml)(after 12 hours, on day 2 (in 24hour), 3 (in 24hour), 5 (in 24hour) and 10 (in 24hour) after surgery)
- length of hospital stay(up to 100 days after surgery)
- length of ICU stay(up to 100 days after surgery)
- Intensive care unit mortality(28 days and 90 days after surgery)
- hospital mortality(up to 100 days after surgery)
- usage of renal replacement therapy (hours)(up to 30 days after surgery)
- length of invasive respirator therapy (hours)(up to 30 days after surgery)
- creatinine in serum(12 hours, day 2, 3, 5 and 10 after surgery)
研究者
Prof. Dr. Christian Wunder
Vice chair and leading senior physician
Wuerzburg University Hospital