Effect of Glucagon on Uterine Contractility at the Time of Embryo Transfer in in Vitro Fertilization
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- Uterine muscle relaxation
研究概览
简要总结
The success of in vitro fertilization is based mainly on uterine implantation embryo. An excessive uterine contractility may interfere with implantation by a movement of the embryo in the uterus. The inhibition of the uterine contractility may have a positive effect on success rate of in vitro fertilization. It is through parenteral injection of glucagon and its spasmolytic effect on various smooth muscles and thereby on the uterine muscle, at the time of embryo transfer, the investigators intend to improve the pregnancy rates obtained after IVF.
详细描述
Women will have a cycle of in vitro fertilization (IVF) and follow the standard protocol established by the clinic ovo or the fertility clinic of CHUM. On the day of embryo transfer, the investigators will administer 1 mg of Glucagon or placebo intramuscularly 10 minutes before the embryo transfer. The uterine contractility will be measured by ultrasound before and after injection to document the impact of Glucagon on it and we will proceed to embryo transfer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women doing fertility treatment at the clinic ovo or fertility clinic of CHUM
- •Less than 40 years old
- •Women with stimulate in vitro fertilization cycle
- •Women able to give her consent
排除标准
- •Body mass index > 35 kg/m2
- •Women with diabetes
- •Women with hypertensive disorders
- •Women with a blood pressure greater or equal to 140/90 mmHg at the randomization visit
- •Cons-indication to taking Glucagon:
- •Hypersensitivity to product
- •Pheochromocytoma or history of pheochromocytoma
- •Insulinoma
- •Taking a beta-blocker (drug interactions)
研究组 & 干预措施
Glucagon
The first recording is a transvaginal ultrasound in midsagittale position for the measurement of the basic uterine contractility 2 minutes before the injection of Glucagon.
The second recording is doing the same way 10 minutes after the Glucagon injection, just before the embryo transfer.
干预措施: Glucagon (Drug)
Sodium chloride 0.9%
The first recording is a transvaginal ultrasound in midsagittale position for the measurement of the basic uterine contractility 2 minutes before the injection of the placebo.
The second recording is doing the same way 10 minutes after the placebo injection, just before the embryo transfer.
干预措施: placebo (Drug)
结局指标
主要结局
Uterine muscle relaxation
时间窗: 30 minutes
Determine if the intramuscular administration of 1mg of Glucagon 10 minutes before the embryo transfer is associated with a uterine muscle relaxation.
次要结局
- Embryo implantation and pregnancy rate(7 weeks)