IRCT201410271556N68已完成2 期
Simvastatin versus Atorvastatin in the treatment of mild to moderate depression in post CABG patients: a double blind randomized clinical trial
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 15 years 至 80 years（—）
- 性别
- All
入选标准
- •1. Patients who have undergone coronary bypass surgery.
- •2. Patients who based on DSM-IV have major depression and based Hamilton rating scale for depression (Ham-D 17 items) their score is => 18.
- •3. No psychiatric symptoms
- •4. Not receiving psychotropic drugs
- •5. Not receiving antidepressants during the last month
- •6. Do not receiving ECT during the last two months
- •7. No thyroid problem
- •8. Age between 15 and 80 years
- •9. No liver dysfunction
- •10. No Muscular disorders
- •11. Not receiving other antilipid drugs
- •12. No hypersensitivity to statins
- •13. LDL => 80
- •14. Liver enzymes not being elevated at the time of recruitment
- •15. No life threatening disease
- •16. No neurological disorders
- •17. Not being pregnant
- •18. No breast feeding
- •19. Giving informed consent
- •Exclusion criteria:
- •1. Existing other disorders rather than depression, including Bipolar disorders, Schizophrenia, and other psychotic disorders
- •2. History of drug abuse or dependency within the last three months
- •3. Probability of suicide or its tendency during the last year
- •4. Women who are going to be pregnant within the next few months
- •5. Women who use OCP for pregnancy prevention
- •6. Patients who have received antidepressants during the last month
- •7. Patients who have received ECT withing the last two months
- •8. Patients who need un-usual psychiatric treatments
- •9. Patients with liver dysfunction
- •10. Muscular disorders
- •11. Receiving other antilipid drugs
- •12. Hypersensitivity to statins
- •13. LDL < 80
- •14. Elevated liver enzymes at the time of recruitment
- •15. Life threatening diseases
- •16. Neurological diseases
排除标准
- 未提供
研究者
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