A comparative study of inducing agent Propofol and Sodium Thiopental on hemodynamic changes during induction of general anesthesia in hypertensive patients.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Blood pressure values
研究概览
简要总结
In the current era anesthesia is required for almost all surgeries that includes amnesia, analgesia, muscle relaxation and homoeostasis. Ideal induction agent for General Anaesthesia should have hemodynamic stability, minimal respiratory side effects, rapid clearance, lack of pain on injection, rapid return of consciousness. Induction is the most stressful moment of general anaesthesia. Commonly used induction agents are propofol, thiopentone, etomidate and ketamine. Increase in hemodynamic instability is more prominent in hypertensive patients, many times profound decrease in BP is observed. Propofol produce nitric oxide and cause bradycardia and hypotension due to reduction in preload and afterload. This study is aimed at comparing haemodynamic responses associated with anaesthetic induction with propofol and sodium thiopentone in hypertensive patients.
Hypertension is an modifiable risk factor cardiovascular morbidity and mortality. Less than half of those who has hypertension are diagnosed with hypertension others are left undiagnosed. Aetiology of hypertension is a complex
interaction between genetic and Pathophysiological mechanisms which involves multiple systems. Both lifestyle modification and pharmacological therapy are effective in lower blood pressure. Hypertension can primary
(essential hypertension) or secondary hypertension.
In this study hemodynamic responses of propofol and thiopentone in hypertensive is compared. Blood pressure, Heart rate and SPO2 will be measured at regular interval after giving anyone of the drugs. These data will be used compared and the efffect of both drug on hemodynamics in hypertensive patient.
研究设计
- 研究类型
- Interventional
- 分配方式
- Random Number Table
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients undergoing surgery under general anaesthesia with 1) ASA II or III 2) Male or female 3) Controlled hypertensive patient 4) Duration of surgery more than 30 minutes.
排除标准
- •Patient refusal Allergy to any medication Allergy to egg or soya bean History of ischemic heart disease, myocardial infraction, asthma and diabetes mellitus Any other contraindication for the drugs Difficult airway Obesity.
结局指标
主要结局
Blood pressure values
时间窗: baseline, 1 minute, 2minute, 3 minute, 4 minute post administration of induction agents and 1 minute, 2 minute, 3 minute, 4 minute, 5 minute, 6 minute, 7 minute, 8 minute, 10 minute, 15 minute, 20 minute, 25 minute, 30 minute after intubation
次要结局
- Best inhalational agent with respect to hemodynamic stability(baseline, 1 minute, 2minute, 3 minute, 4 minute post administration of induction agents and 1 minute, 2 minute, 3 minute, 4 minute, 5 minute, 6 minute, 7 minute, 8 minute, 10 minute, 15 minute, 20 minute, 25 minute, 30 minute after intubation)