Monitoring Of Salivary cortisol in Anogenital skin Inflammation treated with topical Corticosteroids

Alder Hey Children's Hospital0 个研究点目标入组 55 人开始时间: 2023年10月23日最近更新: 2023年11月6日

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•BOYS: Males 5-15 years who are treatment naïve (no steroid medication of any kind in the previous 3 months) receiving potent topical steroid for pathological or physiological phimosis.
•GIRLS: Pre-pubertal females aged 5-15 years who are treatment naïve (no steroid medication of any kind in the previous 3 months) receiving very potent topical steroid for LS following diagnosis made in the paediatric gynaecology/dermatology clinics.

•1. Patients with oral conditions which could contaminate saliva samples with blood, such as current mouth ulcers or gingivitis.
•2. Patients taking additional medications which are likely to impact on cortisol levels e.g. glucocorticoids, sex steroids, thyroxine, growth hormone, insulin, metformin, opiates, loperamide and azole compounds.
•3. Children with a family history of adrenal insufficiency due to an inherited condition, including congenital adrenal hyperplasia.
•4. Children <5 years of age and children at high risk of choking on the cotton wool roll used to collect the saliva.
•5. The treating clinician does not consider it appropriate to delay treatment whilst the family consider the study and take the pre-treatment samples.
•6. Recent (within 3 weeks) ingestion of liquorice

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