Randomised controlled trial of 24 hours intravenous (IV) antibiotic therapy followed by oral antibiotic therapy versus 72 hours or more IV antibiotic therapy for the successful resolution of acute erysipelas and cellulitis of the lower limb

Barwon Health0 个研究点目标入组 80 人开始时间: 2013年12月13日最近更新: 2020年1月13日

试验速览

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•1.Acute cellulitis of lower limb with consistent clinical features, including; erythema, pain, and swelling with onset within 5 days with either fever on clinical examination or history consistent with fevers and/or chills, rigors, nausea within 5 days prior to presentation
•2.Age > 18 years
•3.Patient is planned for intravenous antibiotics via hospital admission or hospital-in-the-home treatment for cellulitis of the lower limb

•1. Age <18 years
•2. Pregnant female
•3. Immunosuppression including any one of: active chemotherapy in the last 6 weeks, receipt of prednisolone >20mg/ day, or neutropaenia with neutrophil count <0.5 x 109/L or alternative conditions significantly affecting the immune system
•4. Alternative diagnosis, including but not limited to: venous eczema, Diabetic foot infection, Surgical site (wound) infection or other open wound
•5. Penetrating injury or bite
•6. Suspected complication such as abscess or necrotising infection
•7. Septic shock or other reasons for intensive care unit admission
•8. Oral antibiotics effective against cellulitis for > 48 hours or IV antibiotics effective against cellulitis for >24 hours. (including receipt of flucloxacillin, dicloxacillin, cephalexin, cephazolin, clindamycin and Vancomycin).
•9. Patient unwilling to participate or in the opinion of investigators will be unable to comply with the requirements of the study.

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