Study of Microbiological Diversity in Exhaled Air in Adult Subjects With Chronic Obstructive Pulmonary Disease (COPD) and Subjects Free of COPD
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 240
- 试验地点
- 2
- 主要终点
- Number and dominant bacterial species in human exhalations of COPD subjects and non-COPD subjects
研究概览
简要总结
COPD and non-COPD patients will be included in the study after collection of their non-objection. The exhalation will be collected to study the microbiological diversity of human exhalations.
a second collection for the year +1 will be made, at the same time (between October and March).
详细描述
The subjects will be recruited during a medical visit in the Departments of Pneumology and Occupational and Environmental Pathologies.
After information and inclusion of the subject in the study, a collection of clinical data, the state of health and the smoking status of the subject will be carried out by the clinical study technician.
A collection of the exhalation will also be carried out by the clinical study technician.
Several groups of subjects will be formed according to pathologies (COPD versus non-COPD), age and smoking status
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with chronic obstructive pulmonary disease
- •Age: over 18
- •For non-COPD
- •Absence of chronic obstructive pulmonary disease
- •Age: between 18 and 30 years old and between 45 and 70 years old
排除标准
- •Taking certain medications in the month preceding the sample (antibiotics, systemic corticosteroids, immunosuppressants)
- •Person under guardianship or curatorship
- •Pregnant or breastfeeding women
- •Person unable to express his/her opposition, person deprived of liberty
- •Existence of a chronic infectious pulmonary pathology such as (dilation of the bronchi, cystic fibrosis)
研究组 & 干预措施
Chronic Obstructive Pulmonary Disease (COPD)
Patients with chronic obstructive pulmonary disease will be recruited from the pulmonology or occupational pathology department. They are either active smokers or ex-smokers. They are over 18 years old
干预措施: collection of human exhalation (Other)
NO-Chronic Obstructive Pulmonary Disease
The no-COPD are controls followed in chi créteil for another pathology. They are between 18 and 30 years old and 45 and 70 years old.
They are either:
- Ex-smoker
- Active smoker
- Non-smoker
干预措施: collection of human exhalation (Other)
结局指标
主要结局
Number and dominant bacterial species in human exhalations of COPD subjects and non-COPD subjects
时间窗: Baseline
number and bacterial species
次要结局
- Number and dominant bacterial species in human exhalations according to age(Baseline)
- Number and dominant bacterial species in human exhalations for patients returning for consultation 1 year apart during the winter season(1 year)
- Number and dominant bacterial species in human exhalations according to smoking status(Baseline)