NCT01272674已完成1 期
Adiponectin Promotes the Migration of Circulating Progenitor Cells Through p38-mediated Induction of the CXCR4 Receptor
University of Leipzig2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2011年1月1日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- migratory capacity of endothelial progenitor cells towards an SDF-1 gradient
研究概览
简要总结
Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells. The molecular mechanisms are only partially understood. Therefore, aim of the present study is to elucidate the effects of Adiponectin on endothelial progenitor cell migration and the underlying signaling pathways. Furthermore, the impact of exercise training on adiponectin-mediated endothelial progenitor cell migration will be investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •≤ 75 years of age
- •stable coronary artery disease
- •preserved left ventricular function
- •physical work capacity of ≥ 50
- •successful elective percutaneous coronary intervention at study begin
排除标准
- •diabetes mellitus
- •hypercholesterolemia
- •untreated hypertension
- •myocardial infarction within the last 4 weeks
- •significant stenosis of the left main coronary artery
结局指标
主要结局
migratory capacity of endothelial progenitor cells towards an SDF-1 gradient
时间窗: 4 weeks
次要结局
未报告次要终点
研究者
Prof. Dr. med. A. Linke
Co-investigator
University of Leipzig
研究点 (2)
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