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临床试验/NCT01320189
NCT01320189已完成不适用

Dietary Protein Requirements and Caloric Over-consumption on Unbalanced Diets

Maastricht University Medical Center2 个研究点 分布在 1 个国家目标入组 81 人开始时间: 2011年5月最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
81
试验地点
2
主要终点
protein intake

研究概览

简要总结

The objective of this study is to determine ad libitum daily energy and protein intake, energy balance and appetite profile in response to protein/carbohydrate and fat ratio over 12 consecutive days, also as a function of age, gender, BMI and FTO polymorphisms.

详细描述

Following the protein leverage hypothesis, energy intake may be a derivative of protein intake. Therefore, in response to an unbalanced menu relative to the usual daily intake target, protein intake should be prioritized. Individuals may over-consume carbohydrate and fat of a menu containing a lower ratio of protein to carbohydrate and fat until the daily intake target amount of protein is ingested, and not the target of total energy intake because of a deficit of protein intake. In contrast, individuals may under-consume energy when the menu has an increased protein to carbohydrate and fat ratio. The protein leverage hypothesis requires evidence for why protein intake is more important than carbohydrate or fat in relation to food intake regulation.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Treatment
盲法
Double (Participant, Investigator)

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • BMI 18-35 kg/m2
  • age between 18-70 years
  • non-smoking
  • not using a more than moderate amount of alcohol (> 10 consumptions/wk)
  • weight stable (weight change < 3 kg during the last 6 months)
  • not using medication or supplements except for oral contraceptives in women

排除标准

  • not healthy
  • using a more than moderate amount of alcohol
  • not being weight stable
  • using medication or supplements except for oral contraceptives in women
  • do not meet the criteria for BMI and age
  • pregnant or lactating
  • allergic for the used food items

研究组 & 干预措施

Protein intake of 5 energy percent

Experimental

干预措施: Differences in protein content of meals (Dietary Supplement)

Protein intake of 15 energy percent

Experimental

干预措施: Differences in protein content of meals (Dietary Supplement)

Protein intake of 30 energy percent

Experimental

干预措施: Differences in protein content of meals (Dietary Supplement)

结局指标

主要结局

protein intake

时间窗: 12 consecutive days

energy balance

时间窗: 12 consecutive days

appetite profile

时间窗: 12 consecutive days

energy intake

时间窗: 12 consecutive days

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Eveline Martens

PhD

Maastricht University Medical Center

研究点 (2)

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Dietary Protein Requirements on Unbalanced Diets | 临床试验