Dietary Protein Requirements and Caloric Over-consumption on Unbalanced Diets
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 81
- 试验地点
- 2
- 主要终点
- protein intake
研究概览
简要总结
The objective of this study is to determine ad libitum daily energy and protein intake, energy balance and appetite profile in response to protein/carbohydrate and fat ratio over 12 consecutive days, also as a function of age, gender, BMI and FTO polymorphisms.
详细描述
Following the protein leverage hypothesis, energy intake may be a derivative of protein intake. Therefore, in response to an unbalanced menu relative to the usual daily intake target, protein intake should be prioritized. Individuals may over-consume carbohydrate and fat of a menu containing a lower ratio of protein to carbohydrate and fat until the daily intake target amount of protein is ingested, and not the target of total energy intake because of a deficit of protein intake. In contrast, individuals may under-consume energy when the menu has an increased protein to carbohydrate and fat ratio. The protein leverage hypothesis requires evidence for why protein intake is more important than carbohydrate or fat in relation to food intake regulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI 18-35 kg/m2
- •age between 18-70 years
- •non-smoking
- •not using a more than moderate amount of alcohol (> 10 consumptions/wk)
- •weight stable (weight change < 3 kg during the last 6 months)
- •not using medication or supplements except for oral contraceptives in women
排除标准
- •not healthy
- •using a more than moderate amount of alcohol
- •not being weight stable
- •using medication or supplements except for oral contraceptives in women
- •do not meet the criteria for BMI and age
- •pregnant or lactating
- •allergic for the used food items
研究组 & 干预措施
Protein intake of 5 energy percent
干预措施: Differences in protein content of meals (Dietary Supplement)
Protein intake of 15 energy percent
干预措施: Differences in protein content of meals (Dietary Supplement)
Protein intake of 30 energy percent
干预措施: Differences in protein content of meals (Dietary Supplement)
结局指标
主要结局
protein intake
时间窗: 12 consecutive days
energy balance
时间窗: 12 consecutive days
appetite profile
时间窗: 12 consecutive days
energy intake
时间窗: 12 consecutive days
次要结局
未报告次要终点
研究者
Eveline Martens
PhD
Maastricht University Medical Center
