The Copmparison of Accuracy of PtcCO2 and in PetCO2 in COPD Patients With NIV Treatment
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- partial arterial pressure of end-tidal CO2 measured by prolong expiration method [PetCO2(P)]
研究概览
简要总结
The chronic obstructive pulmonary disease (COPD) patients with type II respiratory failure always needs PaCO2 test to monitor the changes of disease. Method used mostly nowadays to detect PaCO2 is arterial puncture which is accurate but is invasive, painful and non-dynamic. Noninvasive measurement methods includes end-tidal CO2 (PetCO2), transcutaneous CO2 (PtcCO2) which can monitor the PaCO2 dynamically and noninvasively, but their accuracy is in controversy. Common PetCO2 is especially inaccurate in COPD patients while our team find that the accuracy can be improved by prolong expiration method (PetCO2 (P)).So the investigators want to compare the accuracy of PtcCO2 and PetCO2(P) in AECOPD patients during noninvasive ventilation(NIV).
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •AECOPD patients with type II respiratory failure who need NIV treatment
排除标准
- •hemodynamics is unstable;
- •any other lung disease despite COPD;
- •other diseases influencing experiments: Cognitive impairment disease mouth and nose trauma.
结局指标
主要结局
partial arterial pressure of end-tidal CO2 measured by prolong expiration method [PetCO2(P)]
时间窗: 2 hours
PetCO2(P) will be measured before and after NIV treatment.
partial arterial pressure of transcutaneous CO2 (PtcCO2)
时间窗: 2 hours
PtcCO2 will be measured before and after NIV treatment.
partial arterial pressure of carbon dioxide (PaCO2)
时间窗: 2 hours
PaCO2 will be measured before and after NIV treatment.
次要结局
未报告次要终点
研究者
Zhenfeng He
principal investigator
Guangzhou Medical University