Comparison of Novel Putative Risk Factors for Exertional Heat Illness Between a Military Patient Cohort and Matched Control Cohort During Exercise Heat Stress
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- Diversity of gastrointestinal microbiota
研究概览
简要总结
The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat. These conditions reduce operational effectiveness and expose personnel to a risk of incapacitation and death from exertional heat illness (EHI). The primary aim of this study is to compare putative 'chronic' EHI risk factors between a cohort who have suffered a history of EHI and a control cohort with no EHI history. The secondary aim is to examine the influence of these EHI risk factors on thermoregulation during a standard heat tolerance assessment.
详细描述
Military training and operations present a risk of incapacitation and death from Exertional Heat Illness (EHI). However, widely accepted EHI risk factors are absent in almost half of all United Kingdom (UK) military EHI cases, indicating that a significant number of EHI cases in military personnel involve alternative risk factors. Risk factors for EHI can been classified along a spectrum ranging from acute (e.g. recent poor sleep) to chronic (e.g. low fitness), with the role of chronic risk factors supported by the observation that individuals who have suffered an EHI are at a substantially increased risk of subsequent EHI. The primary aim of this study is to compare putative 'chronic' EHI risk factors (e.g. composition of gastrointestinal (GI) microbiome, infection and inflammation, trait-like psychological factors) between a cohort who have suffered a history of EHI and a control cohort with no EHI history. The secondary aim is to examine the influence of these EHI risk factors on thermoregulation during a standard heat tolerance assessment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individuals with a history of EHI:
- •Previous EHI episode
- •Normal resting ECG
- •Male or female
- •18 - 40 years
- •Control participants:
- •No previous history of EHI
- •Normal resting ECG
- •Male or female
- •18 - 40 years
排除标准
- 未提供
结局指标
主要结局
Diversity of gastrointestinal microbiota
时间窗: Baseline
Measured in stool sample. Assessed by beta diversity score.
Circulating Interleukin 6
时间窗: Post Heat Tolerance Assessment (within 15 minutes of test end)
Measured using ELISA
Abundance of gastrointestinal microbiota
时间窗: Baseline
Measured in stool sample. Assessed at level of phylum.
Detection of sexually transmitted pathogens
时间窗: Baseline
Assessed from urine sample. Measured using cobas CT/NG assays.
Detection of respiratory pathogens
时间窗: Baseline
Assessed from throat swab. Measured using Allplex assays.
Detection of gastrointestinal pathogens
时间窗: Baseline
Assessed from stool swab. Measured using Allplex.
Circulating Claudin 3
时间窗: Post Heat Tolerance Assessment (within 15 minutes of test end)
Measured using ELISA
Circulating C-Reactive Protein
时间窗: Post Heat Tolerance Assessment (within 15 minutes of test end)
Measured using ELISA
Circulating Zonulin
时间窗: Baseline
Measured using ELISA
Circulating lipopolysaccharide binding protein
时间窗: Post Heat Tolerance Assessment (within 15 minutes of test end)
Measured using ELISA
Circulating intestinal fatty acid binding protein
时间窗: Post Heat Tolerance Assessment (within 15 minutes of test end)
Measured using ELISA
Gastrointestinal illness symptomology questionnaire
时间窗: Immediately post Heat Tolerance Assessment
Visual analogue scale (0-10). Higher scores indicate worse symptomology
Respiratory illness symptomology, measured by Jackson common cold questionnaire
时间窗: Baseline
Higher scores indicate worse symptomology
Sleep quality and quantity, measured by Pittsburgh Sleep Quality Index
时间窗: Baseline -3 days
Higher scores indicate worse sleep
Motivation, measured by Motivation scale
时间窗: Baseline -3 days
State-trait anxiety, measured by state-trait anxiety inventory form Y-2
时间窗: Baseline -3 days
Risk taking, measured by the risk-taking inventory
时间窗: Baseline -3 days
Stress, measured by perceived stress scale
时间窗: Baseline -3 days
Mental readiness
时间窗: Baseline
Visual analogue scale (0-100). Higher scores indicate a lower state of mental readiness.
Stress
时间窗: Baseline
Visual analogue scale (0-100). Higher scores indicate a greater state of stress.
Resilience, measured by the Connor-Davidson resilience scale
时间窗: Baseline -3 days
Core temperature
时间窗: Rate of rise from 30 to 60 minutes (or test termination if earlier) of Heat Tolerance Assessment
Measured using a rectal thermistor.
次要结局
- Rating of Perceived Exertion(At 15 minute intervals during Heat Tolerance Assessment)
- Skin Temperature(During Heat Tolerance Assessment)
- Sweat rate(During Heat Tolerance Assessment)
- Heat rate(At 5 minute intervals during the Heat Tolerance Assessment)
- Thermal comfort(At 15 minute intervals during Heat Tolerance Assessment)
- Thermal sensation(At 15 minute intervals during Heat Tolerance Assessment)
研究者
Jo Corbett
Principal Investigator
University of Portsmouth