NCT03867656已完成不适用
Effects of Gut Peptides on Bone Remodeling. KS-4-Diabetes-19
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- CTX
研究概览
简要总结
Both GLP-2 and GIP reduce the bone resorption (measured as CTX) in healthy persons. In this study, we will investigate wether GLP-2 and GIP is reducing CTX in persons with type 2 diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 25 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age 25 to 70 years old.
- •Type 2 diabetes.
- •In Metformin or sulfonylureas
排除标准
- •Treatment with other antidiabetics
- •Osteopososis or gastrointestinal disease
- •Long term steroid treatment
- •Weight change more than 3 kg within the last 3 months.
- •Overweight or intestinal surgery
研究组 & 干预措施
Placebo
Placebo Comparator
Saline
干预措施: Placebo (Other)
GLP-2
Experimental
Glucagon-like peptide 2
干预措施: GLP-2 (Other)
GIP
Experimental
Glucose-dependent insulinotropic polypeptide
干预措施: GIP (Other)
结局指标
主要结局
CTX
时间窗: -10 minutes to 240 minutes
Bone resorption measured as collagen type 1 C-terminal telopeptide (CTX) in serum.
P1NP
时间窗: -10 minutes to 240 minutes
Bone formation measured as procollagen type 1 N-terminal propeptide (P1NP) in serum.
次要结局
- Glucose(-10 minutes to 240 minutes)
- PTH(-10 minutes to 240 minutes)
- Insulin(-10 minutes to 240 minutes)
- GIP(-10 minutes to 240 minutes)
- C-peptide(-10 minutes to 240 minutes)
- GLP-2(-10 minutes to 240 minutes)
- Glucagon(-10 minutes to 240 minutes)
- Sclerostin(-10 min to 240 min.)
- Blood pressure(-10 minutes to 240 minutes)
- Heart rate(-10 minutes to 240 minutes)
研究者
Kirsa Skov-Jeppesen
Principal Investigator
University of Copenhagen
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Gut Peptides and Bone Remodeling in Individuals With Spinal Cord InjurySpinal Cord InjuriesNCT05181150University of Copenhagen20
已完成
不适用
Effects of Gut Peptides on Bone RemodelingHealthyNCT03574064University of Copenhagen10
已完成
不适用
Relationships Between GLP-2 and Markers of Bone Turnover Following FeedingObesityNCT01531907Sheffield Teaching Hospitals NHS Foundation Trust19
已完成
不适用
Gut Hormones and Bone Remodeling in Humans (KS-2)HealthyNCT03573934University of Copenhagen10
已完成
不适用
Glucose-Dependent Insulinotropic Polypeptide - Effects on Markers of Bone Turnover in Patients With Type 1 DiabetesType 1 Diabetes MellitusNCT03195257Mikkel Christensen10