Beliefs and Expectation Effects on Blood Pressure Following Isometric Exercise in Inactive Adults
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Change in Resting Systolic Blood Pressure
研究概览
简要总结
This study investigates how isometric exercise training (IET) affects blood pressure in physically inactive adults. Isometric exercise involves sustained muscle contractions without movement-for example, pushing against a fixed object. Previous research has shown that IET may help reduce blood pressure, but the mechanisms involved are not fully understood.
The purpose of this study is to assess both the immediate (acute) and long-term (chronic) effects of IET on cardiovascular outcomes. Participants will complete a series of lab-based exercise sessions over several weeks. In these sessions, they will perform repeated bouts of isometric leg extensions while seated on an exercise machine designed to measure muscle force.
Throughout the study, researchers will monitor participants' blood pressure, heart rate, and muscle activity. Acute responses-such as post-exercise hypotension (a short-term drop in blood pressure)-will be measured immediately after exercise. Chronic changes, such as resting blood pressure improvements, will be evaluated across the training period.
Additional measurements will include heart rate variability (HRV), which gives insight into autonomic nervous system activity, and electromyography (EMG), which tracks muscle fatigue and activation patterns. These data will help explore potential mechanisms behind the cardiovascular benefits of IET.
By examining how repeated sessions of isometric exercise influence blood pressure and related physiological responses, this research may support the use of IET as a non-pharmacological strategy for managing or preventing hypertension in physically inactive individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
Participants are blinded to group assignment. They are not informed whether they are receiving neutral or expectation-enhancing information, or whether they are in a control group. Due to the nature of the study, the researcher is not blinded.
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 years or older
- •Self-reported physically inactive or insufficiently active (not meeting current physical activity guidelines)
- •Not currently engaged in structured resistance or isometric exercise training
- •Able to attend lab sessions over a 4-week period
- •Provides written informed consent
排除标准
- •Current diagnosis of hypertension requiring medication
- •Any known cardiovascular, neurological, or musculoskeletal condition contraindicating isometric exercise
- •Formal education or professional background in exercise science, physiology, or a related field
- •Pregnant or planning to become pregnant during the study period
- •Inability to follow verbal instructions or complete study protocols
结局指标
主要结局
Change in Resting Systolic Blood Pressure
时间窗: Baseline to Post-Intervention (approximately 4 weeks)
Systolic blood pressure will be measured at rest using a Task Force Monitor prior to and after the isometric exercise intervention period. The primary outcome is the change in resting systolic blood pressure from baseline to final testing. Measurements are taken in a seated position following standard resting protocols.
次要结局
- Change in Diastolic Blood Pressure(Baseline to Post-Intervention (approximately 4 weeks))
- Post-Exercise Hypotension Response(During the first week of the exercise intervention. Sessions 1, 2 and 3.)
- Change in Heart Rate Variability (HRV)(Baseline to Post-Intervention (approximately 4 weeks))
- Change in Muscle Fatigue Markers (EMG)(Baseline to Post-Intervention (Approximately 4 weeks))