Interventions in Math Learning Disabilities: Cognitive and Neural Correlates
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 180
- 试验地点
- 2
- 主要终点
- Change from baseline in symbolic number comparison task performance (reaction time)
研究概览
简要总结
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).
详细描述
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).
To achieve this goal, investigators will use a theoretically-motivated integrated symbolic/non-symbolic (iSNS) intervention with a randomized controlled design to enhance cross-format mapping between symbolic and nonsymbolic representations of quantities. The investigators will develop innovative computational models to investigate individual differences in latent cognitive processes and brain plasticity that contribute to learning, long-term retention, and transfer in children.
The investigators will assess performance in several areas and investigate cognitive and neural mechanisms that support numerical skill acquisition in children with differing levels of math learning abilities.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Elementary school aged children starting from first grade (6-12 years old)
- •IQ: Participants with a Full Scale IQ > 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II).
- •Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests
- •Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests
- •Normal or corrected-to-normal vision and no hearing impairments
- •Inclusion in MRI scan session: Right-handed
排除标准
- •History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.)
- •History of trauma involving head injury
- •Consistent psychiatric medications
- •Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)
研究组 & 干预措施
Integrative Symbolic Non-Symbolic (iSNS) Training
Integrative symbolic non-symbolic (iSNS) training: Over a period of 6 weeks, participants will complete activities that progressively strengthen the mapping of symbolic numerical representations to non-symbolic numerical quantities and enhance fluency in symbolic numerical skills.
干预措施: Interventions in Mathematics and Cognitive Skills - Experimental (Other)
Active Comparator: Active Control Intervention (Working Memory Training)
Active control intervention: Over a period of 6 weeks, participants will complete activities that enhance short-term storage and maintenance of visuospatial or verbal information.
干预措施: Interventions in Mathematics and Cognitive Skills - Active Comparator (Other)
结局指标
主要结局
Change from baseline in symbolic number comparison task performance (reaction time)
时间窗: Baseline and post-intervention (after 6 weeks)
Performance will be measured by children's reaction time (milliseconds) on symbolic number comparison task
Change from baseline in symbolic number comparison task performance (accuracy)
时间窗: Baseline and post-intervention (after 6 weeks)
Performance will be measured by children's accuracy (% trials correct) on symbolic number comparison task
Change from baseline in non-symbolic number comparison task performance (reaction time)
时间窗: Baseline and post-intervention (after 6 weeks)
Performance will be measured by children's reaction time (milliseconds) on non-symbolic number comparison task
Change from baseline in non-symbolic number comparison task performance (accuracy)
时间窗: Baseline and post-intervention (after 6 weeks)
Performance will be measured by children's accuracy (% trials correct) on non-symbolic number comparison task
Change from baseline in latent cognitive measures of symbolic number comparison task performance (drift rate)
时间窗: Baseline and post-intervention (after 6 weeks)
Latent cognitive processing will be measured by drift rate from children's symbolic number comparison task performance
Change from baseline in latent cognitive measures of symbolic number comparison task performance (post-error adjustment)
时间窗: Baseline and post-intervention (after 6 weeks)
Latent cognitive processing will be measured by post-error adjustment from children's symbolic number comparison task performance
Change from baseline in latent cognitive measures of non-symbolic number comparison task performance (drift rate)
时间窗: Baseline and post-intervention (after 6 weeks)
Latent cognitive processing will be measured by drift rate from children's non-symbolic number comparison task performance
Change from baseline in latent cognitive measures of non-symbolic number comparison task performance (post-error adjustment)
时间窗: Baseline and post-intervention (after 6 weeks)
Latent cognitive processing will be measured by post-error adjustment from children's non-symbolic number comparison task performance
Change from baseline in brain activation during symbolic number comparison task performance
时间窗: Baseline and post-intervention (after 6 weeks)
Neural activity will be measured during functional magnetic resonance imaging (fMRI) symbolic number comparison task. Data will consist of beta values from individual subject contrast maps for Near vs Far contrast from the whole-brain GLM fMRI analysis.
Change from baseline in brain activation during non-symbolic number comparison task performance
时间窗: Baseline and post-intervention (after 6 weeks)
Neural activity will be measured during functional magnetic resonance imaging (fMRI) non-symbolic number comparison task. Data will consist of beta values from individual subject contrast maps for Near vs Far contrast from the whole-brain general linear model (GLM) fMRI analysis.
次要结局
- Change from baseline in symbolic addition task performance (reaction time)(Baseline and post-intervention (after 6 weeks))
- Change from baseline in symbolic addition task performance (accuracy)(Baseline and post-intervention (after 6 weeks))
研究者
Vinod Menon
Professor
Stanford University