A prospective randomised study to compare the efficacy of Nebulized Dexmedetomidine and Nebulized Magnesium Sulphate for Attenuation of Hemodynamic Response during Laryngoscopy and Tracheal Intubation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 93
- 试验地点
- 1
- 主要终点
- To compare the effectiveness of nebulised magnesium sulfate and dexmedetomidine by measuring changes in heart rate , Systolic BP , Diastolic BP and Mean BP during and after laryngoscopy
研究概览
简要总结
Research comparing nebulised magnesium sulfate and dexmedetomidine is scarce. Most studies focus on intravenous administration leaving a gap in understanding their relative efficacy and safety when administered through nebulisation. Magnesium sulphate has high therapeutic index and no known interactions with commonly used anti-hypertensive drugs as compared to Dexmedetomidine where bradycardia, hypotension and AV block is encountered. So, this prospective randomized study is planned to compare the efficacy and safety profile of nebulised magnesium sulfate and dexmedetomidine in attenuating the hemodynamic stress response during laryngoscopy and Tracheal intubation in patients undergoing elective surgery under general anesthesia.
OBJECTIVE
1.To compare the effectiveness of nebulised magnesium sulfate and dexmedetomidine by measuring changes in heart rate , Systolic BP , Diastolic BP and Mean BP during and after laryngoscopy.
2.To estimate the incidence of postoperative sore throat and other side effects.
3.To assess serum magnesium levels in all the groups
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •American Society of Anesthesiologists (ASA) grade I or II.
- •Age 18–60 years.
- •Elective surgery under general anesthesia requiring laryngoscopy and intubation.
排除标准
- •Patient refusal.
- •Contraindications to these drugs.
- •History of difficult airway MPS grade 3/4 or failed intubation.
- •Chronic use of sedatives, oral magnesium supplements.
结局指标
主要结局
To compare the effectiveness of nebulised magnesium sulfate and dexmedetomidine by measuring changes in heart rate , Systolic BP , Diastolic BP and Mean BP during and after laryngoscopy
时间窗: 18 Months
次要结局
- 1.To estimate the incidence of postoperative sore throat & other side effects.(2.To assess serum magnesium levels in all the groups)
研究者
Rohit Kumar
Adesh Medical College and Hospital Mohri Kurukshetra