Prediction of TAPSE/PASP Ratio for Hypotension Due to General Anesthesia Induction in Pulmonary Resection Surgery
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- echocardiography
研究概览
简要总结
TAPSE, one of the methods for evaluating right ventricular systolic function; It is a bar parameter that can easily measure apex-basal shortening and provides specific information about global RV function. TAPSE/PASP can be calculated as load-independent parameters to evaluate RV function. Because RV function is sensitive to change in afterload, known as the RV-pulmonary circulation (PC) connection.
This study aims to identify patients who are candidates for hypotensive events due to general anesthesia in a hemodynamically stable population.
详细描述
TAPSE, one of the methods for evaluating right ventricular systolic function; It is a bar parameter that can easily measure apex-basal shortening and provides specific information about global RV function. TAPSE/PASP can be calculated as load-independent parameters to evaluate RV function. Because RV function is sensitive to change in afterload, known as the RV-pulmonary circulation (PC) connection.
This study aims to identify patients who are candidates for hypotensive events due to general anesthesia in a hemodynamically stable population.
Patients will be measured by transthoracic echocardiography in the preoperative period, 15-30 minutes before induction.
Basal hemodynamic parameters and non-invasive and/or hemodynamic values will be recorded every two minutes after induction until surgical incision.Patients with a 30% decrease in SBP from the baseline and a decrease in MAP below 65 mmHg in the first 10 minutes after anesthesia induction will be considered to have hypotension. Patients will be divided into 2 groups: 'with' and 'without' hypotension.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Written informed consent;
- •18-75 years old
- •ASA Physical Status 1-3;
- •Patients planned for pulmonary resection surgery
排除标准
- •The patient is pregnant
- •After cardiac surgery
- •Severe pulmonary hypertension
- •Severe valve disease
- •Hypertrophic or dilated cardiomyopathy
- •Presence of acute myocardial infarction
- •Patients with severe visual or hearing impairment/disability
- •ASA physical status IV or V
- •Ischemic heart disease, conduction disorder.
- •History of long-term use of certain medications (β-blockers, angiotensin converting enzyme inhibitors, analgesics, sedatives or tricyclic antidepressants)
结局指标
主要结局
echocardiography
时间窗: 30 minute
TAPSE/ PASP (mm/mmHg)
次要结局
- tension(4-5 hours)
研究者
ferdi gülaştı
Assistant prof.dr.
Aydin Adnan Menderes University