NCT01976884已完成不适用
Expression and the Clinical Significance of Neutrophil PD-L1 During Sepsis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 71
- 主要终点
- PD-L1 level on neutrophils
研究概览
简要总结
Immunosuppression is the leading cause of death in septic patients. Neutrophils are classical components of innate immunology, but recent studies showed that neutrophils might display antigen presenting function and inhibit lymphocyte proliferation by expressing programmed cell death 1 ligand 1 (PD-L1). Whether neutrophils express PD-L1 and its role in immunosuppression during sepsis remain unclear.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with severe sepsis
- •patients with sepsis after PCNL for infectious kidney stone
- •patients with pancreatic cancer
- •healthy volunteers
排除标准
- •patients with immunodeficient diseases
- •patients who accept glucocorticoid or immunosuppressant
- •patients with an age older than 18 years
- •patients providing the informed consent
结局指标
主要结局
PD-L1 level on neutrophils
时间窗: within 24h after recruitment
PD-L1 level on neutrophils was compared between different populations.
次要结局
- 28-day mortality(28 days after diagnosis of sepsis)
研究者
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