Role of bacterioPhages In gut Microbiome composition and glucose metabolism in Metabolic Syndrome subjects

Investigator initiated0 个研究点目标入组 24 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•Caucasian male/female
•Age: =18 years old
•BMI: =25 kg/m2
•At least 3 of the following criteria:
•oFasting plasma glucose =5.6 mmol/L OR HOMA-IR index =2.5 (HOMA-IR is measured as (fasting insulin (pmol/L) x fasting glucose (mmol/L)) / 135)
•oWaist-circumference =102 cm
•oHDL-cholesterol =1.02 mmol/L
•oBlood pressure =130/85 mmHg
•oTriglycerides =1.7 mmol/L
•Subjects should be able to give informed consent

•A history of cardiovascular event (cerebrovascular accident (CVA), myocardial infarction (MI)) or pacemaker implantation
•Use of any medication including proton pump inhibitors, antibiotics and pro-/prebiotics in the past three months or during the study period
•(Expected) prolonged compromised immunity (due to recent cytotoxic chemotherapy or human immunodeficiency viruses (HIV) infection with a CD4 count < 240/mm3)
•Presence of overt type 1 diabetes mellitus (T1DM) or T2D
•History of chronic diarrhoea (=3 stools/day for >4 weeks), chronic obstipation (<2 defecations/week for >3 months), Irritable Bowel Syndrome (IBS) (according to Rome IV criteria) or Inflammatory Bowel Disease (IBD).
•Smoking or illicit drug use (MDMA/amphetamine/cocaine/heroin/GHB) in the past three months or use during the study period
•Use of >5 units of alcohol daily on average in the past three months or use of >2 units of alcohol during the study period
•History of cholecystectomy

发起方

Investigator initiated