Variations of Portal Flow During the Respiratory Cycle in Healthy Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- flow rates variation between the fast sequence averaged values and the standard sequence
研究概览
简要总结
The analysis of portal vein blood flow is important when assessing the severity and progression of liver disease. It is important to understand normal liver regulation in order to appreciate the evaluation of the effect of treatment during the disease progression. The influence of respiration on hepatic hemodynamics is still poorly understood, although some studies have shown a significant impact. The purpose of this project is to quantify the blood flow variations in the portal vein at different positions during the respiratory cycle by using a fast MRI sequence and an Echo Planar (EPI) acquisition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 18 ans
- •Healthy subject without history of hepatic disease
排除标准
- •history of hepatic pathology
- •pregnant woman
- •claustrophobia
- •major obesity
- •any contraindication to MRI exam
结局指标
主要结局
flow rates variation between the fast sequence averaged values and the standard sequence
时间窗: 30 minutes
flow rates variation between the fast sequence averaged values and the standard sequence during free breathing.
次要结局
未报告次要终点