Investigating gastric emptying of cow milk in healthy subjects, who either do or do not experience gastro-intestinal discomfort after cow milk ingestion - MIlk DIgestion study (MiDi study)

Wageningen Universiteit0 个研究点目标入组 30 人开始时间: 待定最近更新: 2024年4月15日

试验速览

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•Drinking cow milk (maximum of 200ml/week for those who declare to not drink milk habitually and a minimum of 700ml/week for those who declare to drink milk habitually)
•Do report/do not report GI discomfort after milk consumption (depending on study group)
•Not lactose intolerant (tested with lactose breath test)
•BMI:18.5 * 30 kg/m2
•Age: 18 - 60 years
•Healthy (self-reported)
•Having given informed consent
•Need to be willing to be informed about incidential findings of pathology

•Having a history of medical or surgical events related to the GI tract that may give rise to GI complaints
•Medical drug use that influences the GI tract*s normal function, e.g. the motility, pH etc: among others use of proton pump inhibitors, antacids, anti-depressants etc.
•Medical drug use that influence the GI tract*s microbiom: antibiotic use within 1 months prior to the pre-study screenings day
•Daily consumption of probiotics
•Weekly use of laxatives
•Lactose intolerance (medically diagnosed) and cow milk allergy
•Reported unexplained weight loss or weight gain of > 5 kg in the month
•Reported slimming or medically prescribed diet, vegan or macrobiotic life-style
•Alcohol consumption of more than 14 glasses/week
•Smoking more than 4 cigarettes a day
•Being pregnant, having the intention to get pregnant, lactating or being under postmenopausal hormonal treatment
•Not having a general practitioner
•Having a contra-indication to MRI scanning

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