NCT01730599Unknown不适用
A Longitudinal 5 Years Follow up Study in Parkinson's Disease (PD) Patients Carriers of the LRRK2 Gene G2019S Mutation
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- change from baseline in updrs motor and total scores
研究概览
简要总结
This is a longitudinal study in patients with Parkinson's Disease (PD) carriers of a genetic mutation - substitution of gly with ser in position 2019 (G2019S) in the leucine-rich repeat kinase 2 (LRRK2) gene. The purpose of this study is to explore the association between genetic mutations in the known genes and their influence on disease manifestation over few years of follow up
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •parkinson'd disease patients that already participated in a pasr cross sectional study
排除标准
- •subjects with cognitive decline by the parameters defined in Diagnostic and Statistical Manual of Mental Disorders (DSM)- IV
- •subjects with psychiatric disorder
- •subjects unable to sign a consent form
结局指标
主要结局
change from baseline in updrs motor and total scores
时间窗: the participants will be followed for 5 years. the measurements will be taken evry 18 month.
次要结局
未报告次要终点
研究者
研究点 (1)
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