Scintigraphic Comparison of Lung Deposition With Two Nebulizers During Invasive Mechanical Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Pulmonary deposition
研究概览
简要总结
Many devices are available for nebulising drug solution during invasive mechanical ventilation. Vibrating-mesh nebulizers ensure the highest lung deposition output. A recent international survey on aerosol therapy during mechanical ventilation (Ehrmann et al. 2013) reported that jet nebulizers remained the mostly used.
The aim of this study is to compare lung deposition of a radiolabeled administered with both nebulizers during invasive mechanical ventilation by planar scintigraphy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Invasive mechanical ventilation
- •Healthy lungs
排除标准
- •Discontinued procedure due to adverse events.
研究组 & 干预措施
Nebulization with a vibrating-mesh nebulizer
Nebulization performed with a vibrating-mesh nebulizer
干预措施: technetium-99m - Diethylenetriaminepentaacetic acid (Drug)
Nebulization with a vibrating-mesh nebulizer
Nebulization performed with a vibrating-mesh nebulizer
干预措施: Vibrating-mesh nebulizer (Device)
Nebulization with a vibrating-mesh nebulizer
Nebulization performed with a vibrating-mesh nebulizer
干预措施: Planar scintigraphy (Other)
Nebulization with a vibrating-mesh nebulizer
Nebulization performed with a vibrating-mesh nebulizer
干预措施: Preoperative spirometry (Other)
Nebulization with a jet nebulizer
Nebulization performed with a jet nebulizer
干预措施: technetium-99m - Diethylenetriaminepentaacetic acid (Drug)
Nebulization with a jet nebulizer
Nebulization performed with a jet nebulizer
干预措施: Jet Nebulizer (Device)
Nebulization with a jet nebulizer
Nebulization performed with a jet nebulizer
干预措施: Planar scintigraphy (Other)
Nebulization with a jet nebulizer
Nebulization performed with a jet nebulizer
干预措施: Preoperative spirometry (Other)
结局指标
主要结局
Pulmonary deposition
时间窗: Immediately after nebulization by imaging assessment, an expected average of 30 minutes
次要结局
- Penetration index(Immediately after nebulization by imaging assessment, an expected average of 30 minutes)
- Lung function(Preoperative assessment, the day before inclusion)
- Mechanical ventilation settings(During nebulisation time, an expected average of 15 minutes)