The Effect of Ketone Esters on Forearm Glucose Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Forearm glucose net balance
研究概览
简要总结
Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important tool for treating disease or recovering from exercise. The purpose of this research is to determine if a ketone drink can increase sugar uptake in our muscles. This research will provide new knowledge about the regulation of blood sugar.
详细描述
Impaired skeletal muscle glucose uptake following a meal ("insulin resistance"), is a primary risk factor for developing type 2 diabetes. We and others have consistently shown that ingesting exogenous ketones can reduce blood glucose concentration. Mechanistically, this must arise through reduced glucose release (i.e. from liver), and/or increased uptake (i.e. into skeletal muscle). Our current MRC-funded work is focussing on ketone-liver interactions in patients with type 2 diabetes. Here we aim to investigate how KE influence skeletal muscle glucose metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
Coded, known only to one independent individual
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-40
排除标准
- •Any diagnosed metabolic health condition
- •Diagnosed Cardiovascular disease
- •Use of medications deemed by research team to affect study outcomes
- •Recent history of musculoskeletal injury
- •Aged >40 or <18
- •Allergy to ingredients in the supplement, including ketones, lactose or milk protein
研究组 & 干预措施
Ketone supplementation
100 mL flavoured drink containing 0.3 g/kg ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate; ΔG®, University of Oxford; https://www.deltagketones.com)
干预措施: Ketone supplement (Dietary Supplement)
Placebo
Placebo with bitter agent to flavour match
干预措施: Placebo supplement (Dietary Supplement)
结局指标
主要结局
Forearm glucose net balance
时间窗: 3 hours
Net balance of blood glucose across a forearm following a mixed meal tolerance test
次要结局
- Forearm amino acid net balance(3 hours)
- Serum insulin concentrations(3 hours)
- Ketone concentration(3 hours)
- Forearm non-esterified fatty acid net balance(3 hours)