An observational neuroimaging and neurophysiological study investigating the visual pathway in Huntington*s disease. - Visual pathway in HD.

eids Universitair Medisch Centrum0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•* Between 18 and 65 years of age at time of visit
•* Ability to undergo MRI scanning
•* Written informed consent must be obtained from the participant;If the participant is a manifest HD gene carrier:
•* Gene positive tested with CAG repeat length of * 36 in the HTT gene
•* UHDRS-TMS > 5;If the participant is a premanifest HD gene carrier:
•* Gene positive tested with CAG repeat length of * 36 in the HTT gene
•* UHDRS-TMS * 5;If the participant is a control subject:
•* Gene negative tested for HD or without family history of HD
•* No other known cognitive, neurological or psychiatric disorders

•* Impaired primary visual ability (<0.5) or ophthalmic disorders
•(including amblyopia or color vision deficiency)
•* Additional major co-morbidities not related to HD
•(e.g. cardiovascular diseases, hypertension, diabetes mellitus, and/or other neurological disorders)
•* History of severe head injury
•* Contra-indication for MRI (metallic implants/devices, claustrophobia)
•* Participation in intervention trials
•* Pregnancy
•* Inability to understand the information about the protocol

发起方