Identification of Metabolic Phenotypes Associated With Melanoma Metastasis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 400
- 试验地点
- 2
- 主要终点
- Glucose Utilisation in the TCA cycle
研究概览
简要总结
The goal of this study is to observe metabolic features associated with human melanoma tumors.
详细描述
This is a single center, correlative study designed to assess metabolic features of melanoma tumors in patients. The study will involve the collection of melanoma tissue at the time of surgical biopsy or excision. All samples will be assessed by mass spectrometry for metabolomic analysis. A subset of patients will have received [U-13C]glucose infusions which will be utilized for isotope tracing metabolic analysis. Relevant clinical data (eg survival, metastasis) will be correlated with metabolic findings.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with known or probable malignant melanoma lesions requiring surgical biopsy or excision.
- •Subjects of all races and ethnic origins over age 18.
排除标准
- •Not a surgical candidate
- •Poorly controlled diabetes
结局指标
主要结局
Glucose Utilisation in the TCA cycle
时间窗: 5 years
In patients receiving a \[U-13C\]Glucose infusion, assess glucose utilization in the TCA cycle by melanoma tumors (defined as fractional enrichment of 13C-label in TCA metabolites)
次要结局
- Relapse free survival(5 years)
- Overall Survival(5 years)
- Development of Lymph Node or Distant Metastasis(5 years)
研究者
Jennifer Gill
ASSISTANT PROFESSOR
University of Texas Southwestern Medical Center