Effects of Yoga on Pressor and Endothelial Function in Responses to Sodium Loading in African American Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Change in arterial stiffness from low- to high-sodium dietary conditions.
研究概览
简要总结
This investigation aims to determine the effects of a 4-week yoga intervention on sodium-induced pressor and endothelial function responses as well as markers of renal sodium handling in African American adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •African American
- •Adults ages 18-60 years
排除标准
- •pregnancy or within 60 days postpartum
- •having taken blood pressure (including diuretics beta-blockers, ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers) or statin medications within the past 3 months (statins have been demonstrated to reduce oxidative stress which could impact flow-mediated dilation);
- •infection (viral or other) within the past 4 weeks;
- •having adrenal or endocrine tumors (these could impact BP);
- •renal disease defined as a glomerular filtration rate (GFR) of less than 60 (creatinine will be tested at initial screening and GFR will be calculated);
- •prior myocardial infarction; vii) known coronary heart disease;
- •personal history of stroke;
- •heart failure;
- •cardiac arrhythmias;
- •chronic obstructive pulmonary disease;
- •recent chest pain or dyspnea;
- •orthopedic limitations that preclude the execution of yoga postures;
- •current insulin dependence;
- •currently taking steroid medications;
- •currently undergoing chemotherapy or radiation;
- •having practiced yoga or yogic breathing techniques at least once weekly consistently within the past 3 months;
- •heat intolerance or electrolyte imbalances (hypo- or hyper-natremia or hypo- or hyper-kalemia).
结局指标
主要结局
Change in arterial stiffness from low- to high-sodium dietary conditions.
时间窗: Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.
Cardio-ankle vascular index will be measured after 3 days of low- and 3 days of high-sodium intake.
Change in endothelial function from low- to high-sodium dietary conditions.
时间窗: Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.
Flow-mediated dilation will be measured via ultrasound imaging of the upper arm after 3 days of low- and 3 days of high- sodium dietary conditions.
Change in blood pressure from low- to high-sodium dietary conditions
时间窗: Measurements will be completed after 3 days of low and 3 days of high sodium intake at baseline and after 4 weeks for both conditions.
Blood pressure will be measured after 3 days of very low sodium and 3 days of high sodium intake.
次要结局
- Change in urinary sodium excretion from low- to high-sodium dietary conditions.(Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.)
研究者
Stacy Hunter
Assistant Professor
Texas State University