NCT01280006已完成1 期
Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Arterial Blood Pressure
研究概览
简要总结
The study has been designed to assess the effect of cyclooxygenase inhibition on blood pressure, cerebral blood flow, ventilation and renal hemodynamics following chronic intermittent hypoxia exposure.
详细描述
The study will specifically evaluate:
- Cardiovascular effect of cyclooxygenase inhibitors on cerebral, vascular, blood pressure and homeostatic responses following chronic intermittent hypoxia exposure.
- Ventilatory response of cyclooxygenase inhibitors following chronic intermittent hypoxia exposure
- Evaluate the renal hemodynamic effect of chronic intermittent hypoxia exposure and cyclooxygenase inhibition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male subjects
- •18 - 45 years of age
- •Informed written consent
排除标准
- •Any history of cardio-respiratory diseases, ongoing medication, smoking, trauma, acute illnesses, collagen vascular diseases, rheumatoid arthritis, osteoarthritis
结局指标
主要结局
Arterial Blood Pressure
时间窗: Six weeks
Blood pressure will be monitored during all three protocols.
Cerebral Blood Flow
时间窗: Six weeks
The cerebral blood flow will be mesauresed during each testing days of all three protocols.
次要结局
- Ventilatory Response(Six weeks.)
- Renal Hemodynamics(Six weeks)
研究者
Marc Poulin
Prof Dr.
University of Calgary
研究点 (2)
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