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临床试验/NCT06677723
NCT06677723已完成不适用

Differential Effects of High-frequency Versus Low-frequency Exercise Training in Adolescents With Elevated Depressive Symptoms.

Je Bouge Pour Mon Moral1 个研究点 分布在 1 个国家目标入组 43 人开始时间: 2024年3月11日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
43
试验地点
1
主要终点
changes in depressive symptoms

研究概览

简要总结

This research project aims to examine the antidepressant effects of different exercise routines on adolescent depression, which has risen significantly in recent years. Depression, particularly prevalent among adolescents at a global rate of around 12%, is associated with reduced positive emotional responses and difficulties in managing negative emotions. Prior studies indicate that physical activity can boost positive moods, like feelings of excitement and calm, potentially leading to overall mood stabilization with regular exercise. However, results on how exercise influences negative moods remain inconsistent. This study will compare two exercise routines-a single 60-minute weekly session versus four 15-minute weekly sessions of moderate-intensity running-over three weeks to determine which approach has a stronger effect on reducing depressive symptoms in adolescents.

详细描述

Depression is a mental disorder that affects millions of people globally every year. This mental health issue is particularly prominent in adolescents populations, where depression has been found to increase at a greater rate than in adults over the last decade. In concrete terms, the global current prevalence of depressive disorders (major depressive disorder and dysthymia) is about 7-8% in adults worldwide, whereas it is around 12% among adolescents.

Depression is characterized by a limited capacity to inhibit negative emotions and a dampening of positive affective and emotional reactions.

There is strong evidence that physical activity increases pleasant-activated states like excitement and vigor both immediately following a bout of exercise and more accumulatively, and some studies show that physical activity enhances pleasant-deactivated affective states like calmness or relaxation. Over time, these acute affective responses to physical activity may accumulate to chronically regulate core affect. One logical implication of all this is that shorter but more frequent exercise sessions throughout the week will offer repeated doses of mood improvement, leading to a more stable mood over time, which should predict greater reductions in depressive symptoms.

Previous studies have reported inconsistent and inconclusive findings for the influence of physical activity on unpleasant core affects, and the general pattern in previous research is that physical activity has a more pronounced effect on positive affect than negative affect. Although, recent findings suggest that daily moderate to vigorous physical activity can decrease the level of depressed and angry affects in adolescents.

Therefore, the current randomized controlled study aims to compare the antidepressant effects of a 3-week exercise program with either one weekly 60-minute session or four weekly 15-minute sessions of moderate-intensity running among adolescents (in which findings have been mixed to date).

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 22 Years(Adult)
性别
All
接受健康志愿者
否

入选标准

  • •baseline PHQ-9 score > 9 (i.e., "moderate depression")

排除标准

  • •unability to read and understand French language
  • •specific medical contraindications for physical activity

研究组 & 干预措施

RUN_1*60

Experimental

exercise training including one weekly running session (60-min long) for 3 weeks

干预措施: physical activity (Behavioral)

RUN_4*15

Experimental

exercise training including 4 weekly running sessions (15-min long) for 3 weeks

干预措施: physical activity (Behavioral)

CONTROL

No Intervention

control group

结局指标

主要结局

changes in depressive symptoms

时间窗: PHQ-9 completed the day before and the day after the 3-week long exercise program

Depression scores will be obtained using the self-report instrument "Patient Health Questionnaire-9" (PHQ-9). This self-report measure has 9 items that assess depressive symptoms. Items are rated on a 4-point scale ranging from 0 to 3. The final score is obtained by adding the score of each item and can range from 0 to 27 with higher scores indicating greater severity of depressive symptoms. A score of 0-4 indicates no depression, scores 5-9 indicate mild depression, 10-14 indicates moderate depression, 15-19 indicates moderately severe depression, and 20 or above indicates severe depression.

次要结局

未报告次要终点

研究者

发起方
Je Bouge Pour Mon Moral
申办方类型
Other
责任方
Principal Investigator
主要研究者

Fabien Legrand

Principal Investigator

Je Bouge Pour Mon Moral

研究点 (1)

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