NCT01000350进行中（未招募）不适用
Intravenous Saline on Exercise Tolerance in Orthostatic Intolerance
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Difference in VO2max between saline day and placebo day
研究概览
简要总结
The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meet diagnostic criteria of Postural Tachycardia Syndrome (POTS) 28
- •Age between 18-65 years
- •Male and female are eligible (although the majority of POTS patients are female).
- •Able and willing to provide informed consent
排除标准
- •Presence of medical conditions that can explain postural tachycardia (e.g., acute dehydration, medications)
- •Pregnancy
- •Other factors which in the investigator's opinion would prevent the subject from completing the protocol.
- •Patients who are bedridden or chair-ridden
研究组 & 干预措施
Exercise Post Saline
Experimental
Saline infusion 1L hours before exercise test
干预措施: Saline (Drug)
Placebo
Placebo Comparator
Placebo given prior to exercise test
干预措施: Placebo (Other)
结局指标
主要结局
Difference in VO2max between saline day and placebo day
时间窗: Within 2 week
VO2max will be measured hours after saline and after placebo. The 2 interventions will be less than 2 weeks apart.
次要结局
- Exercise capacity/Maximal Load (Watts) during peak VO2(Less than 2 weeks)
- Cardiac output between exercise tests (inert gas rebreathing technique)(2-10 Days between exercise tests)
研究者
Satish R. Raj
Adjunct Associate Professor of Medicine
Vanderbilt University Medical Center
研究点 (1)
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