Development of a Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Assessment of the slope of terminal D-3MH/3MH decay curve post-dosing.
研究概览
简要总结
The long-term objective of this research is to develop a non-invasive approach for early assessment of which patients are at high risk for future development of skeletal muscle atrophy. The investigators hypothesize that the rate constant for the terminal portion of the isotope decay curve following ingestion of a single oral dose of deuterated-3-methylhistidine (D-3MH) provides an accurate measure of this increased risk and that this rate constant can be measured non-invasively from timed spot urine samples. In addition, the investigators hypothesize that ingestion of a meat-containing meal will stimulate synthesis of skeletal muscle proteins to a greater extent than a non-meat-containing meal.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 85 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •30-85 years
- •Body Mass Index (BMI) <30 kg/m2
排除标准
- •Uncontrolled hypertension
- •Glomerular filtration rate less than 60 mL/min/1.73 m2
- •History of recurrent gastrointestinal bleeding
- •Unable or unwilling to provide informed consent
- •Ongoing anti-coagulant therapy
结局指标
主要结局
Assessment of the slope of terminal D-3MH/3MH decay curve post-dosing.
时间窗: Post-dosing 12 to 22 hours
Assess the slope of the terminal D-3MH/3MH decay curve for the post-dosing time period as calculated using plasma or urine samples and after a meat-containing or meat-free test meal.
次要结局
未报告次要终点